[Frontiers in Bioscience 13, 2356-2363, January 1, 2008] 2356 DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis
نویسندگان
چکیده
1 Institute of Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, Germany, 2 IMTM GmbH, Department Immunopharm, Magdeburg, Germany, 3 University Clinic of Dermatology and Venereology, Otto-von-Guericke University Magdeburg, Germany, 4 Institute of Experimental Internal Medicine, Otto-von-Guericke University Magdeburg, Germany, 5 Institute of Biochemistry and Biotechnology, Department of Natural Sciences I, Martin-Luther-University HalleWittenberg, Halle, Germany, 6 Departments of Immunology and Pharmacology, University of Connecticut Health Center, Farmington, CT
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TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
The T cell marker CD26/dipeptidyl peptidase (DP) IV is associated with an effector phenotype and markedly elevated in the human CNS disorder multiple sclerosis. However, little is known about the in vivo role of CD26/DP IV in health and disease, and the underlying mechanism of its function in CNS inflammation. To directly address the role of CD26/DP IV in vivo, we examined Th1 immune responses ...
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